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David Moyes shuffles his pack from Thursday night in Genk, making eight changes.
The only survivors are Declan Rice, Vladimir Coufal and Jarrod Bowen from the 1-1 draw.
There is no Nayef Aguerd or Aneglo Ogbonna in the squad, so Thilo Kehrer partners Kurt Zouma in the heart of the defence. Michail Antonio leads the line.
Not an ideal preparation for Arsenal as Oleksandr Zinchenko is ruled out with a groin issue so Kieran Tierney is the only change from the team that started at Liverpool.
Eddie Nketiah returns on the bench having missed the past month with an ankle problem.
Arsenal team news – Zinchenko out, Tierney in
Team to play West Ham: Ramsdale, White, Holding, Gabriel, Tierney, Partey, Xhaka, Odegaard, Saka, Jesus, Martinelli
Subs: Turner, Smith Rowe, Kiwior, Trossard, Jorginho, Vieira, Nelson, Walters, Nketiah
West Ham team news
Team to play Arsenal: Fabianski, Coufal, Zouma, Kehrer, Cresswell, Rice, Soucek, Paqueta, Bowen, Benrahma, Antonio
Subs: Areola, Anang, Johnson, Fornals, Lanzini, Downes, Cornet, Ings, Emerson
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